Dr. A.T. (Arjan) Groot

Postdoctoral researcher - Maastro Lab

Dr. Arjan J. Groot studied medical biology and clinical chemistry at the Institute for Chemical and Medical Laboratory Research in Alkmaar. From 2000-2003 he worked as a research technician at the Human and Clinical Genetics Department, Leiden UMC, supervised by Prof. Dr. J.T. den Dunnen and Prof. Dr. S.M. van der Maarel on the project: “Expression grids: a novel approach to study gene/environment interactions” focusing on the applications of VHH antibodies in the field of neuromuscular disorders. In 2003 he started as a PhD student at the Department of Pathology, VU Medical Center, on a project entitled: “Identification of proteins involved in stabilization and activation of HIF-1 alpha, a hypoxia upregulated genes crucial in carcinogenesis and tumor progression”, under the supervision of Prof. Dr. P.J. van Diest and Prof. Dr. E. van der Wall. In 2004 the project was continued at the Department of Pathology, University Medical Center Utrecht. In 2008 he received his PhD in Medicine at University Utrecht in 2008, entitled: HIF-1 Regulation and Cancer Therapy. In 2008 he joined as a post-doc the lab of Prof. Dr. F.G. Giancotti, Department of Cell Biology, Memorial Sloan-Kettering Cancer Center (MSKCC) in New York City, USA. He worked on the protein Merlin encoded by the NF2 gene and found inactivated in the cancer syndrome Neurofibromatosis type 2 (NF2). In 2010 he joined Maastro Lab as a post-doc to work on Notch receptor signaling in the group of Prof. dr. Vooijs. In 2015 he became a staff scientist at Maastro Lab. I made the personal choice to pursue a scientific career devoted to the study of cancer. My main interest is fundamental research of tumor biology and understanding of what drives different cancerous processes. After years of research, we have identified one of these processes and developed a new class of potential cancer therapeutics, which I am very excited about, that is why I like what I do. I vallue family, generosity, compassion, learning, work and discovery. Areas of expertise: www.researchgate.net/profile/Arjan_Groot