Trials

The effect of low-dose radiotherapy on pain in early osteoarthritis of the hip

Clinically node negative breast cancer patients undergoing breast conserving therapy: sentinel lymph node procedure versus follow-up

Neo-adjuvant chemotherapy followed by surgery vs. neo-adjuvant chemotherapy and subsequent chemoradiotherapy followed by surgery vs. neo-adjuvant chemoradiotherapy followed by surgery in resectable gastric cancer

Influence of the intestinal microbiome on the outcome of treatment with preoperative chemoradiotherapy in patients with resectable oesophageal carcinoma

Prospective data collection initiative on colorectal cancer

The (cost)effectiveness of neoadjuvant folfirinox versus neoadjuvant gemcitabine based chemoradiotherapy and adjuvant gemcitabine for (borderline) resectable pancreatic cancer

National registration of patients with liver metastases treated with stereotactic body radation therapy.

Rectal preserving treatment for early rectal cancer. A multi-centered randomised trial of radical surgery versus adjuvant radiotherapy after local excision for early rectal cancers

Evaluating the applicability of a mobile application in the communication with trial participants and investigating the feasibility and preferences of a mobile application for delivering patient registered outcome measures (PROMs) compared to paper questionnaires

External beam radiochemotherapy and MRI based adaptive BRAchytherapy in locally advanced CErvical cancer

Randomised Phase III Trial of molecular profile-based versus standard recommendations for adjuvant radiotherapy for women with early stage endometrial cancer

A nurse-led sexual rehabilitation programme for women with gynaecological cancers receiving radiotherapy: a randomized multicentre trial

Evaluation of the impact of a decision aid tool for patients with advanced larynx cancer and assessment of its influence on shared decision making.

Uniform FDG-PET guided GRAdient Dose prEscription to reduce late Radiation Toxicity (UPGRADE-RT): a randomised controlled trial with dose reduction to the elective neck in head and neck squamous cell carcinoma

A phase 3 study to compare Nivolumab plus CCRT followed by Nivolumab plus Ipilimumab or Nivolumab plus CCRT followed by Nivolumab vs CCRT followed by Durvalumab in previously untreated, locally advanced non-small cell lung cancer.

Elderly with locally advanced Lung cancer: Deciding through geriatric Assessment  on the oPtimal Treatment strategy

It is a multicentre, randomised, controlled open-label phase II clinical trial testing the hypothesis that a combination of (SAB)R and immunocytokineL19-IL2 increases the progression-freesurvival in patients with limited metastatic NSCLC. After randomisation by minimization, patients will be assigned either to the experimental arm (E-arm) or tothe control arm(C-arm).

Patients continue the same immune therapy they already received and get radiotherapy to one lesion. The lesion may or may not be symptomatic, but it should be a lesion that increased in size, i.e. containing resistant cells, according to RECIST 1.1 criteria. The preferred radiotherapy dose is 24 Gy in 3 fractions (dosage on the 10 Gy isodose is allowed), but other fractionation schedules (e.g. 30 Gy/ 10 fractions, 20 Gy/ 5 fractions, 20-24 Gy / 1 fraction for SRS) are allowed if these are standard for a certain location or palliative indication in the body.

A phase III trial of marizomib in combination with standard temozolomide-based radiochemotherapy versus standard temozolomide-based radiochemotherapy alone in patients with newly diagnosed glioblastoma.

Ependymoma in Adults, Evaluation and Treatment Protocol

Primary intracranial germ-cell tumours in adults; evaluation and treatment protocol

A randomized, placebo controlled phase 2b/3 study of ABT-414 with concurrent chemoradiation and adjuvant Temozolomide in subjects with newly diagnosed glioblastoma (GBM) with Epidermal Growth Factor Receptor (EGFR) Amplification (Intellance 1)

Medulloblastoma in Adults Treatment Protocol, Dutch Society for Neuro-Oncology (LWNO)

Prostate cancer Immune profiling before, during and after HDR-brachytherapy in local relapsed prostate cancer.

The impact of the implementation of a decision aid tool for prostate cancer patients on the decision making process

Demonstrate that the ProSpace is safe and effective in reducing the volume of the rectum receiving radiation in prostate cancer patients.