Cancer types
  • Gynaecology
Title of study
Image guided intensity modulated External beam radiochemotherapy and MRI based adaptive BRAchytherapy in locally advanced CErvical cancer
Version Number
Approval Date 
1.0, April 2016
Short Title
Embrace II
Study site
Principle Investigator
Richard Pötter, Medical University of Vienna
Investigator Maastro
Dr L. Lutgens
Sponsor
Medical University of Vienna
Trial registry
Objectives 

• To systematically apply IMRT with daily IGRT as well as advanced image guided adaptive BT in a prospective multi-centre setting
• To systematically implement a dose prescription protocol for IGABT
• To implement systematic contouring, prescription and reporting for EBRT CTV and OARs
• To administer EBRT in different targets which are adapted to the risk of nodal and systemic failure: to improve para-aortic and systemic control in high risk patients and not to decrease lymph node control in low risk and intermediate risk patients
• To systematically administer simultaneous chemotherapy to EBRT to reach prescribed dose in as many patients as possible, in particular in high risk patients
• To benchmark an outstanding high level of local, nodal and systemic control as well as survival with application of advanced EBRT, BT and chemotherapy within limited overall treatment time
• To benchmark a low incidence of intermediate

Primary Endpoint 

Local control, nodal control, systemic control, overall survival and morbidity and quality of life

Secondary Endpoints 

Comprise cancer specific survival, and disease specific survival