Cancer types
  • Neuro-oncology
Title of study
Effect of stress and exercize on the outcome after chemo-radiation
Version Number
Approval Date 
1, 3 March 2022
Short Title
Ependymoma in Adults
Study site
Principle Investigator
Investigator Maastro
D. Eekers / K. Zegers
Trial registry

Is stress a prognostic factor for the overall- or progression free- survival of patients with glioblastoma (GBM)? We will focus on evaluating the relationship between stress and survival after completion of STUPP treatment protocol for patients under 70 years of age with GBM. We will include objective stress measurements like physiological measures with a smart watch and biomarker based stress assessment.

Primary Endpoint 
Secondary Endpoints 

• Is stress a prognostic factor for the quality of life of patients with GBM?
• Is stress an prognostic factor for dose limiting toxicities and/or early termination of the treatment?
• Is there a relationship between stress and treatment response measures on MRI imaging?
• Is there a relationship between dexamethasone use, the stress measures and outcome variables?