Cancer types
Title of study
Rectal preserving treatment for early rectal cancer. A multi-centered randomised trial of radical surgery versus adjuvant radiotherapy after local excision for early rectal cancers
Version Number
Approval Date 
7.0, January 2016
Short Title
Study site
Principle Investigator
Dr J. B. Tuynman, dept. of surgery, VU University Medical Center
Investigator Maastro
Dr J. Buijsen
VU University Medical Center
Trial registry

To determine the oncological safety, treatment related morbidity, and the functional outcome of rectal preserving therapy for early rectal cancer; local excision followed by adjuvant chemo-radiotherapy is compared to local excision followed by completion radical resection of intermediate risk early rectal cancer Primary Endpoint Local recurrence after 3 year follow-up. Secondary Endpoints Secondary Mortality, morbidity, stoma rate, long term interventions, functional outcomes, health related quality of life (HRQoL) and costs

Primary Endpoint 
Secondary Endpoints